Premular® (Ze 440) is a natural medicine clinically proven for the symptomatic relief of premenstrual syndrome (PMS); including symptoms of irritability, anger, headache, bloating and breast tenderness.1,2 Vitex agnus castus (Chaste tree) has a long history of use for hormonal conditions and menstrual complaints. Premular provides a clinically trialled and highly effective tablet extract of Vitex agnus castus, an evidence-based chaste tree product for the management of PMS.3-5

What is Premular used for?

Premular provides natural relief from the physical and behavioural symptoms of PMS.1,2

PMS symptoms are linked to various hormonal changes through the menstrual cycle. The unique extract of Vitex found in Premular helps to balance these hormones through reducing prolactin levels, which are thought to be in excess in PMS.6 This may help to reduce the following PMS symptoms:

• Headaches
• Bloating
• Breast tenderness
• Anger
• Irritability
• Moodiness

Safety & efficacy

Premular has demonstrated consistent efficacy in clinical trials, including a double-blind placebo-controlled study published in the British Medical Journal.1 Evidence published only last year has confirmed that Premular is more effective, when compared to other doses of Chaste tree, for the relief of PMS symptoms.5

Premular is manufactured in Switzerland by Zeller AG, a herbal medicine company with over 130 years of experience in the research and production of natural medicines.

The tablets are easy to take and very well tolerated, with millions of doses prescribed worldwide. Premular has also been assigned a ‘well established medicinal use status’ by the European Medicines Agency, a status based on its history, evidence and excellent tolerability.3,4

Premular's unique formulation

Premular tablets contain a specific extract of Vitex agnus castus (Ze 440) that is manufactured in Switzerland under patented production methods. This ensures a high quality extract with batch-to-batch consistency.

Premular is clinically proven, it is the exact product that has been used in clinical trials. This is very important for natural medicine as there can be great variance between natural products, even if they appear to use the same active ingredients, due to the plant that is used, growing methods, harvesting processes and manufacturing methods. The outcomes of clinical studies for natural medicines may therefore only apply to the exact product that has been tested.

Directions & dosage

Adults: 1 tablet a day, continued throughout the month.

Premular tablets are easy to take and very well tolerated. Dosing should be started within the first few days of the menstrual cycle (within the first few days of menstrual bleeding) and continued throughout the month. Consistent symptom improvement is expected after 3 months of using Premular.

Always read the label. Use only as directed. If symptoms persist, or the condition recurs, it is important to speak with a healthcare professional.